Identification of common variants associated with human hippocampal and intracranial volumes
Articolo
Data di Pubblicazione:
2012
Citazione:
Identification of common variants associated with human hippocampal and intracranial volumes / J.L. Stein, S.E. Medland, A.A. Vasquez, D.P. Hibar, R.E. Senstad, A.M. Winkler, R. Toro, K. Appel, R. Bartecek, O. Bergmann, M. Bernard, A.A. Brown, D.M. Cannon, M.M. Chakravarty, A. Christoforou, M. Domin, O. Grimm, M. Hollinshead, A.J. Holmes, G. Homuth, J. Hottenga, C. Langan, L.M. Lopez, N.K. Hansell, K.S. Hwang, S. Kim, G. Laje, P.H. Lee, X. Liu, E. Loth, A. Lourdusamy, M. Mattingsdal, S. Mohnke, S.M. Maniega, K. Nho, A.C. Nugent, C. O'Brien, M. Papmeyer, B. Putz, A. Ramasamy, J. Rasmussen, M. Rijpkema, S.L. Risacher, J.C. Roddey, E.J. Rose, M. Ryten, L. Shen, E. Sprooten, E. Strengman, A. Teumer, D. Trabzuni, J. Turner, K. Eijk, T.G.M. Erp, M. Tol, K. Wittfeld, C. Wolf, S. Woudstra, A. Aleman, S. Alhusaini, L. Almasy, E.B. Binder, D.G. Brohawn, R.M. Cantor, M.A. Carless, A. Corvin, M. Czisch, J.E. Curran, G. Davies, M.A.A. Almeida, N. Delanty, C. Depondt, R. Duggirala, T.D. Dyer, S. Erk, J. Fagerness, P.T. Fox, N.B. Freimer, M. Gill, H.H.H. Goering, D.J. Hagler, D. Hoehn, F. Holsboer, M. Hoogman, N. Hosten, N. Jahanshad, M.P. Johnson, D. Kasperaviciute, J.W. Kent, P. Kochunov, J.L. Lancaster, S.M. Lawrie, D.C. Liewald, R. Mandl, M. Matarin, M. Mattheisen, E. Meisenzahl, I. Melle, E.K. Moses, T.W. Muehleisen, M. Nauck, M.M. Noethen, R.L. Olvera, M. Pandolfo, G.B. Pike, R. Puls, I. Reinvang, M.E. Renteria, M. Rietschel, J.L. Roffman, N.A. Royle, D. Rujescu, J. Savitz, H.G. Schnack, K. Schnell, N. Seiferth, C. Smith, V.M. Steen, M.C.V. Hernandez, M. Heuvel, N.J. Wee, N.E.M. Van Haren, J.A. Veltman, H. Voelzke, R. Walker, L.T. Westlye, C.D. Whelan, I. Agartz, D.I. Boomsma, G.L. Cavalleri, A.M. Dale, S. Djurovic, W.C. Drevets, P. Hagoort, J. Hall, A. Heinz, C.R. Jack, T.M. Foroud, S. Le Hellard, F. Macciardi, G.W. Montgomery, J.B. Poline, D.J. Porteous, S.M. Sisodiya, J.M. Starr, J. Sussmann, A.W. Toga, D.J. Veltman, H. Walter, M.W. Weiner, J.C. Bis, M.A. Ikram, A.V. Smith, V. Gudnason, C. Tzourio, M.W. Vernooij, L.J. Launer, C. DeCarli, S. Seshadri, O.A. Andreassen, L.G. Apostolova, M.E. Bastin, J. Blangero, H.G. Brunner, R.L. Buckner, S. Cichon, G. Coppola, G.I. Zubicaray, I.J. Deary, G. Donohoe, E.J.C. Geus, T. Espeseth, G. Fernandez, D.C. Glahn, H.J. Grabe, J. Hardy, H.E.H. Pol, M. Jenkinson, R.S. Kahn, C. McDonald, A.M. McIntosh, F.J. McMahon, K.L. McMahon, A. Meyer-Lindenberg, D.W. Morris, B. Mueller-Myhsok, T.E. Nichols, R.A. Ophoff, T. Paus, Z. Pausova, B.W. Penninx, S.G. Potkin, P.G. Saemann, A.J. Saykin, G. Schumann, J.W. Smoller, J.M. Wardlaw, M.E. Weale, N.G. Martin, B. Franke, M.J. Wright, P.M. Thompson, the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Consortium. - In: NATURE GENETICS. - ISSN 1061-4036. - 44:5(2012), pp. 552-561.
Abstract:
Identifying genetic variants influencing human brain structures may
reveal new biological mechanisms underlying cognition and
neuropsychiatric illness. The volume of the hippocampus is a biomarker
of incipient Alzheimer's disease(1,2) and is reduced in
schizophrenia(3), major depression(4) and mesial temporal lobe
epilepsy(5). Whereas many brain imaging phenotypes are highly
heritable(6,7), identifying and replicating genetic influences has been
difficult, as small effects and the high costs of magnetic resonance
imaging (MRI) have led to underpowered studies. Here we report
genome-wide association meta-analyses and replication for mean bilateral hippocampal, total brain and intracranial volumes from a large
multinational consortium. The intergenic variant rs7294919 was
associated with hippocampal volume (12q24.22; N = 21,151; P = 6.70 x
10(-16)) and the expression levels of the positional candidate gene TESC
in brain tissue. Additionally, rs10784502, located within HMGA2, was
associated with intracranial volume (12q14.3; N = 15,782; P = 1.12 x
10(-12)). We also identified a suggestive association with total brain
volume at rs10494373 within DDR2 (1q23.3; N = 6,500; P = 5.81 x 10(-7)).
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
J.L. Stein, S.E. Medland, A.A. Vasquez, D.P. Hibar, R.E. Senstad, A.M. Winkler, R. Toro, K. Appel, R. Bartecek, O. Bergmann, M. Bernard, A.A. Brown, D.M. Cannon, M.M. Chakravarty, A. Christoforou, M. Domin, O. Grimm, M. Hollinshead, A.J. Holmes, G. Homuth, J. Hottenga, C. Langan, L.M. Lopez, N.K. Hansell, K.S. Hwang, S. Kim, G. Laje, P.H. Lee, X. Liu, E. Loth, A. Lourdusamy, M. Mattingsdal, S. Mohnke, S.M. Maniega, K. Nho, A.C. Nugent, C. O'Brien, M. Papmeyer, B. Putz, A. Ramasamy, J. Rasmussen, M. Rijpkema, S.L. Risacher, J.C. Roddey, E.J. Rose, M. Ryten, L. Shen, E. Sprooten, E. Strengman, A. Teumer, D. Trabzuni, J. Turner, K. Eijk, T.G.M. Erp, M. Tol, K. Wittfeld, C. Wolf, S. Woudstra, A. Aleman, S. Alhusaini, L. Almasy, E.B. Binder, D.G. Brohawn, R.M. Cantor, M.A. Carless, A. Corvin, M. Czisch, J.E. Curran, G. Davies, M.A.A. Almeida, N. Delanty, C. Depondt, R. Duggirala, T.D. Dyer, S. Erk, J. Fagerness, P.T. Fox, N.B. Freimer, M. Gill, H.H.H. Goering, D.J. Hagler, D. Hoehn, F. Holsboer, M. Hoogman, N. Hosten, N. Jahanshad, M.P. Johnson, D. Kasperaviciute, J.W. Kent, P. Kochunov, J.L. Lancaster, S.M. Lawrie, D.C. Liewald, R. Mandl, M. Matarin, M. Mattheisen, E. Meisenzahl, I. Melle, E.K. Moses, T.W. Muehleisen, M. Nauck, M.M. Noethen, R.L. Olvera, M. Pandolfo, G.B. Pike, R. Puls, I. Reinvang, M.E. Renteria, M. Rietschel, J.L. Roffman, N.A. Royle, D. Rujescu, J. Savitz, H.G. Schnack, K. Schnell, N. Seiferth, C. Smith, V.M. Steen, M.C.V. Hernandez, M. Heuvel, N.J. Wee, N.E.M. Van Haren, J.A. Veltman, H. Voelzke, R. Walker, L.T. Westlye, C.D. Whelan, I. Agartz, D.I. Boomsma, G.L. Cavalleri, A.M. Dale, S. Djurovic, W.C. Drevets, P. Hagoort, J. Hall, A. Heinz, C.R. Jack, T.M. Foroud, S. Le Hellard, F. Macciardi, G.W. Montgomery, J.B. Poline, D.J. Porteous, S.M. Sisodiya, J.M. Starr, J. Sussmann, A.W. Toga, D.J. Veltman, H. Walter, M.W. Weiner, J.C. Bis, M.A. Ikram, A.V. Smith, V. Gudnason, C. Tzourio, M.W. Vernooij, L.J. Launer, C. DeCarli, S. Seshadri, O.A. Andreassen, L.G. Apostolova, M.E. Bastin, J. Blangero, H.G. Brunner, R.L. Buckner, S. Cichon, G. Coppola, G.I. Zubicaray, I.J. Deary, G. Donohoe, E.J.C. Geus, T. Espeseth, G. Fernandez, D.C. Glahn, H.J. Grabe, J. Hardy, H.E.H. Pol, M. Jenkinson, R.S. Kahn, C. McDonald, A.M. McIntosh, F.J. McMahon, K.L. McMahon, A. Meyer-Lindenberg, D.W. Morris, B. Mueller-Myhsok, T.E. Nichols, R.A. Ophoff, T. Paus, Z. Pausova, B.W. Penninx, S.G. Potkin, P.G. Saemann, A.J. Saykin, G. Schumann, J.W. Smoller, J.M. Wardlaw, M.E. Weale, N.G. Martin, B. Franke, M.J. Wright, P.M. Thompson, the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Consortium
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