Benomyl affects the microtubule cytoskeleton and the glutathione level of mammalian primary cultured hepatocytes
Articolo
Data di Pubblicazione:
1995
Citazione:
Benomyl affects the microtubule cytoskeleton and the glutathione level of mammalian
primary cultured hepatocytes / C. Urani, E. Chiesara, P. Galvani, L. Marabini, A. Santagostino, M. Camatini. - In: TOXICOLOGY LETTERS. - ISSN 0378-4274. - 76:2(1995), pp. 135-144.
Abstract:
Rat primary hepatocyte cultures have been used to study the effect of Benomyl alone or in combination with Pirimiphos-methyl. The results presented demonstrate that Benomyl alone is responsible for the microtubular disorganization in both a time- and dose-dependent manner, that the effect is reversible after the agent is removed, and that Benomyl is a potent glutathione-depleting agent. Pirimiphos-methyl, alone or combined with Benomyl had no effect on microtubule organization, but reinforced the decrease in glutathione.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
C. Urani, E. Chiesara, P. Galvani, L. Marabini, A. Santagostino, M. Camatini
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