Suitability of the old fowl rectal caecum preparation for investigating the selectivity of β-adrenergic drugs
Articolo
Data di Pubblicazione:
1998
Citazione:
Suitability of the old fowl rectal caecum preparation for investigating the selectivity of β-adrenergic drugs / R. Carcano, C. Belloli, F. Arioli, C. Beretta. - In: JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS. - ISSN 1056-8719. - 40:4(1998 Nov), pp. 221-225.
Abstract:
We tested alpha- and beta-adrenergic drugs on isolated strips of fowl rectal caecum from 14- to 16-week-old Warren hens. Basal tone and spontaneous motility were dose-dependently reduced by isoprenaline and all the selective beta-agonists tested (except xamoterol) with the following order of potency: isoprenaline=fenoterol=procaterol=clenbuterol>dobutamine> SR58611A. The results indicate that this tissue preparation consists almost entirely of beta2-adrenoceptors. This preparation may, therefore, be considered a suitable assay for discriminating beta1- from beta2-agonists according to their selectivity.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
α- and β-adrenergic drugs; β-agonist selectivity; Fowl caecum test
Elenco autori:
R. Carcano, C. Belloli, F. Arioli, C. Beretta
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