Occult Hepatitis B in patients with hepatocellular carcinoma and controls with and without hepatitis C virus infection
Poster
Data di Pubblicazione:
2004
Citazione:
Occult Hepatitis B in patients with hepatocellular carcinoma and controls with
and without hepatitis C virus infection / A. Tagger, M.L. Ribero, E. Menatti, F. Azzario, U. Gelatti, L. Covolo, G. Nardi. - In: JOURNAL OF HEPATOLOGY. - ISSN 0168-8278. - 40:Suppl. 1(2004), pp. 84-85. ((Intervento presentato al 39th. convegno Annual Meeting of the European Association for the Study of the Liver (EASL) tenutosi a Berlin, Germany nel 2004.
Abstract:
Background: Hepatitis B virus (HBV), hepatitis C virus (HCV) and alcohol intake have been recognized as the the main causes of hepatocellular carcinoma (HCC) in developed countries. We investigated the prevalence of occult HBV infection in HBsAg-negative HCC cases and controls with and without HCV infection (NBNC). Methods: Between 1995-2002 we prospectively recruited 417 patients with a first diagnosis of HCC as cases and 534 subjects unaffected by liver diseases as controls. Among cases, 204 HCV RNA-positive and 213 NBNC patients, and among controls, 37 HCV RNA-positive and 497 NBNC subjects were tested for the presence of occult HBV. DNA was extracted by proteinase K and phenol/chloroform. HBV DNA was detected by in-house PCR with nested primers (detection limit 500 copies/ml) from highly conserved S-gene region encompassing a-determinant. Results: The relations between occult HBV infection and each of the other risk factors for HCC are shown in table. An increased risk statistically significant for HCC (OR = 5.4) was estimated among HCV RNA-negative subjects and among subjects who drank < 60 g/day of alcohol (OR = 6.8). An interaction was found between occult HBV infection and both HCV infection and heavy alcohol intake. Conclusions: These findings provide a new perspective on the role of occult HBV infection in the HCC aetiology.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
A. Tagger, M.L. Ribero, E. Menatti, F. Azzario, U. Gelatti, L. Covolo, G. Nardi
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