Tissue factor A-603G genotype associates with carotid intima-media thickness in subjects undergoing cardiovascular risk prevention
Abstract
Data di Pubblicazione:
2006
Citazione:
Tissue factor A-603G genotype associates with carotid intima-media thickness in subjects undergoing cardiovascular risk prevention / K. Gertow, D. Colnago, M. Amato, J.P. Werba, D. Baldassarre, M. Camera, E. Tremoli. - In: HAEMATOLOGICA. - ISSN 0390-6078. - 91:s2(2006), pp. 13-13. ((Intervento presentato al 19. convegno CONGRESSO DELLA SOCIETÀ ITALIANA PER LO STUDIO DELL’EMOSTASI E DELLA TROMBOSI (SISET) tenutosi a Milano, Italy nel 2006.
Abstract:
Tissue factor (TF), key initiator of coagulation, is also ascribed a non-haemostatic
function in inflammation, cell migration and proliferation,
suggesting a role of TF not only in thrombosis but also in atherosclerosis
development. Polymorphisms in the TF gene promoter have been
shown to modulate the expression of TF, and thereby potentially also its
involvement in atherosclerosis and individual predisposition to atherosclerotic
disease. Hence, this study was aimed at investigating associations
between TF promoter polymorphisms and carotid intima-media
thickness (IMT), a well-established surrogate marker of atherosclerotic
disease. To this end, the TF A-603G polymorphism was analyzed in 316
subjects enrolled in a primary and secondary cardiovascular risk prevention
programme, with measurements of carotid IMT by B-mode ultrasound.
Also, the TF Ins-1208Del polymorphism was investigated in a
limited number of subjects, which confirmed the previously reported
complete concordance between the -603A and -1208Del alleles. The
subjects were aged 60.2±8.4 years, 80% were male, and 78% were
undergoing secondary prevention with a history of coronary, cerebrovascular,
or peripheral atherosclerotic disease. Both mean and maximum
carotid IMT (measured at the common carotid artery, carotid bifurcation,
and internal carotid artery) differed significantly according to A-603G
genotype, being highest in -603N A (n=93), intermediate in NG (n=161)
and lowest in G/G (n=62) (mean IMT: A/A 1.31±0.36 mm, NG
1.27±0.33 mm, G/G 1.19±0.32 mm; max IMT: A/A 2.36±0.88 mm, NG
2.26±0.85 mm, 2.05±0.88 mm; both p<0.05; adjusted for age, gender, and
statin treatment). In summary, a significant association between TF promoter
genotype and carotid IMT was observed, perhaps mediated via
alterations of TF expression levels in the circulation or within the carotid
vessel wall. These findings support the hypothesis that TF plays a role
in the atherosclerotic process, beyond its well-known role in haemostasis
and thrombosis, thus further implicating TF not only in thrombotic
complications of atherosclerotic disease, but also in plaque progression.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
K. Gertow, D. Colnago, M. Amato, J.P. Werba, D. Baldassarre, M. Camera, E. Tremoli
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