Data di Pubblicazione:
1991
Citazione:
Influence of sulbactam plus ampicillin on theophylline clearance / M. Cazzola, G. Santangelo, E. Guidetti, R. Mattina, M. Caputi, G. Girbino. - In: INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY RESEARCH. - ISSN 0251-1649. - 11:1(1991), pp. 11-5-15.
Abstract:
The effect of sulbactam/ampicillin (500 mg/1000 mg) every 12 hours taken for seven days on the steady-state pharmacokinetics of theophylline was studied among 12 patients suffering from chronic obstructive pulmonary disease. Theophylline concentrations were measured serially for 12 h by the method of polarized immunofluorescence (Abbott TDx system). No influence of sulbactam/ampicillin was detectable on the theophylline half-life, clearance or volume of distribution. It was concluded that both drugs could be administered concomitantly without any dosage adjustment of theophylline.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Fluorescence Polarization Immunoassay; Lung Diseases, Obstructive; Drug Interactions; Half-Life; Humans; Adult; Ampicillin; Theophylline; Sulbactam
Elenco autori:
M. Cazzola, G. Santangelo, E. Guidetti, R. Mattina, M. Caputi, G. Girbino
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