Convenient synthesis of stereospecifically deuteriated glycines from glutamic acid using a combination of enzymatic and chemical methods
Articolo
Data di Pubblicazione:
1985
Citazione:
Convenient synthesis of stereospecifically deuteriated glycines from glutamic acid using a combination of enzymatic and chemical methods / E. Santaniello, R. Casati, A. Manzocchi. - In: JOURNAL OF THE CHEMICAL SOCIETY. PERKIN TRANSACTIONS. I. - ISSN 0300-922X. - :0(1985), pp. 2389-2392.
Abstract:
Chiral glycines (1a) and (1b) have been synthesized starting from stereospecifically deuteriated 4-aminobutanoic acids (3a) and (3b). Enzymatic decarboxylation of (2S)-glutamic acid (2a) in 2H2O and (2R,S)-[2,4,4-2H3]glutamic acid (2b) + (2c) in H 2O afforded (3a) and (3b), respectively. Chemical transformations of deuteriated pyrrolidinones (4a) and (4b) afforded stereospecifically labelled glycines (1a) and (1b) in good yields.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
E. Santaniello, R. Casati, A. Manzocchi
Link alla scheda completa: