Antihypertensive and antithrombotic activities of 6-(substitutedphenyl)-5-hydroxymethyl-4,5-dihydro-3(2H)pyridazinones
Articolo
Data di Pubblicazione:
1987
Citazione:
Antihypertensive and antithrombotic activities of 6-(substitutedphenyl)-5-hydroxymethyl-4,5-dihydro-3(2H)pyridazinones / D. Barlocco, A. Martini, G.A. Pinna, M.M. Curzu, F. Sala, M. Germini. - In: IL FARMACO. EDIZIONE SCIENTIFICA. - ISSN 0430-0920. - 42:8(1987), pp. 585-594.
Abstract:
The synthesis of a series of 6-(4R-phenyl)-5-hydroxymethyl-4,5-dihydro-3(2H)pyridazinones is reported. The compounds were evaluated for their oral antihypertensive activity in rats and some of them [(V b), R = NH2] and [(V c), R = NHCOCH3] were found to induce a high decrease in systolic blood pressure. Moreover all the compounds displayed an antithrombotic activity comparable to, or greater than, that of ASA.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
D. Barlocco, A. Martini, G.A. Pinna, M.M. Curzu, F. Sala, M. Germini
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