Synthesis and pharmacological activity of 4-carbamoyl-5-aryl-6-methyl-4,5-dihydropyridazin-3(2H)ones
Articolo
Data di Pubblicazione:
1992
Citazione:
Synthesis and pharmacological activity of 4-carbamoyl-5-aryl-6-methyl-4,5-dihydropyridazin-3(2H)ones / G.A. Pinna, F. Sardu, M.M. Curzu, M. Satta, A. Peana, G. Cignarella, D. Barlocco. - In: IL FARMACO. - ISSN 0014-827X. - 47:4(1992), pp. 449-463.
Abstract:
A new series of 4-carbamoyl-5-aryl-6-methyl-4,5-dihydropyridazin-3(2H)-ones have been synthesized and tested for their antiinflammatory and analgesic properties. Amongst the test compounds, only 31 showed antiinflammatory activity, though of shorter duration than that of indomethacin, taken as reference drug. On the contrary, many derivatives displayed relevant analgesic activity, 4 - the only 4,5-dehydroderivative - being the most potent in the writhing test. In the hot plate test 3b, 3f and 3k were found to possess the most significant analgesic properties.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
G.A. Pinna, F. Sardu, M.M. Curzu, M. Satta, A. Peana, G. Cignarella, D. Barlocco
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