Design and synthesis of nonpeptide angiotensin II receptor antagonists featuring acyclic imidazole-mimicking structural units
Articolo
Data di Pubblicazione:
1998
Citazione:
Design and synthesis of nonpeptide angiotensin II receptor antagonists featuring acyclic imidazole-mimicking structural units / M. Angiolini, L. Belvisi, D. Poma, A. Salimbeni, N. Sciammetta, C. Scolastico. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - 6:11(1998), pp. 2013-2027.
Abstract:
Extensive molecular modelling studies, including conformational analysis and the comparison of molecular electrostatic potential distributions, were used to evaluate structural parameters of new antagonists containing acyclic replacements of the N=C-N imidazole region. The synthesis and the biological screening of a series of acyl biphenyltetrazole derivatives were planned and realized to gain an insight into the structure-activity relationships of this unusual class of Angiotensin II antagonists. Copyright (C) 1997 Elsevier Science Ltd.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Antagonists; Antihypertension; Molecular modelling
Elenco autori:
M. Angiolini, L. Belvisi, D. Poma, A. Salimbeni, N. Sciammetta, C. Scolastico
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