Proinflammatory lipoxygenase products from peripheral mononuclear cells in patients with rheumatoid arthritis
Articolo
Data di Pubblicazione:
1988
Citazione:
Proinflammatory lipoxygenase products from peripheral mononuclear cells in patients with rheumatoid arthritis / S. Colli, D. Caruso, E. Stragliotto, G. Morazzoni, A. Aletti, G. Galli, B. A. Canesi, E. Tremoli. - In: JOURNAL OF LABORATORY AND CLINICAL MEDICINE. - ISSN 0022-2143. - 112:3(1988 Sep), pp. 357-362.
Abstract:
The formation of 5-lipoxygenase products (5-hydroxyeicosatetraenoic acid [5-HETE], leukotriene B4 [LTB4], and leukotriene C4 [LTC4]) by polymorphonuclear and mononuclear leukocytes isolated from peripheral blood of patients with rheumatoid arthritis was evaluated and compared with the data obtained from a group of control subjects. Although the levels of arachidonic acid metabolites via 5-lipoxygenase pathway by stimulated polymorphonuclear cells were comparable between patients and controls, mononuclear leukocytes from patients synthesized, when stimulated, significantly greater amounts of 5-HETE, LTB4, and LTC4 than did cells isolated from normal subjects. In addition, the release of superoxide anion, stimulated by either a particulate or a soluble stimulus, was increased in mononuclear cells from patients. The enhanced capacity of peripheral mononuclear leukocytes isolated from patients with rheumatoid arthritis to generate proinflammatory metabolites of arachidonic acid and oxygenated species with bactericidal and tissue-damaging properties may contribute to the pathogenesis of this complex disease.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
N-Formylmethionine Leucyl-Phenylalanine; Leukotriene B4; Leukocytes, Mononuclear; Neutrophils; Humans; SRS-A; Calcimycin; Superoxides; Arthritis, Rheumatoid; Hydroxyeicosatetraenoic Acids; Phagocytosis; Cell Aggregation
Elenco autori:
S. Colli, D. Caruso, E. Stragliotto, G. Morazzoni, A. Aletti, G. Galli, B. A. Canesi, E. Tremoli
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