Data di Pubblicazione:
1976
Citazione:
Reduction of certain steroidal 19-sulfonic esters with metal hydrides / E. Santaniello, E. Caspi. - In: JOURNAL OF STEROID BIOCHEMISTRY. - ISSN 0022-4731. - 7:3(1976), pp. 223-227.
Abstract:
For biosynthetic studies we required steroids labeled with 2H and 3H at C 19. The isotopic hydrogens could be introduced sequentially by stepwise reduction of appropriate 19 oxygenated substrates. The key step of the projected sequence was the conversion of the C10 hydroxymethyl to a methyl. The approaches via the hydrogenolysis of steroidal 19 sulfonic esters with metal hydrides was explored and is described. Under conditions tested only 1-2% of the needed C 10 methyl steroids were formed.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
E. Santaniello, E. Caspi
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