Muco-cutaneous expressions of Langerhans cell histiocytosis in adults

Langerhans cell histiocytosis (LCH) is a peculiar disorder of histiocytic proliferation characterized by the accumulation of abnormal Langerhans cells at various body sites, causing damage to affected organs. LCH is rare in adulthood since it usually starts during the first years of life. Our objective was to evaluate reports concerning 17 adult patients with LCH seen in our department since 1970. Clinical findings relating to our patients, and a review of the literature are reported, with special attention being given to the dermatological findings in patients affected by LCH. Our study demonstrated that muco-cutaneous lesions in adults affected by LCH even though having a polymorphous appearance, have typical localizations which may be useful in the diagnosis of LCH.