Data di Pubblicazione:
1990
Citazione:
Immunological study in newborns at risk for HIV-1 infection / G.V. Martino, L.M. Grimaldi, L. Moiola, A. Castagna, R. Novati, A. D'Arminio-Monforte, E. Massironi, P. Marchisio, R. Tornaghi, N. Principi. - In: ACTA NEUROLOGICA. - ISSN 0001-6276. - 12:1(1990 Feb), pp. 71-74.
Abstract:
We have performed an isoelectric focusing study (IEF) to detect the presence of oligoclonal bands (OB) in serum and in 5 of the correspondent cerebrospinal fluid (CSF) from 14 HIV-seropositive mothers and their newborns. CB were also searched in serum from 4 newborns every 3 months over a period of 12 months. OB were present in 8/14 sera and in 3/3 CSF obtained from the mothers; CSF OB were different from the correspondent serum indicating an intrathecal synthesis. OB were also visualized in serum, but not in CSF, from 3 newborns studied at birth: two of them died respectively at 4 and 5 months of age. One of the 4 newborns that were serially studied showed the appearance of OB at 12 months of age. A comparative study between sera obtained at the moment of delivery from the mother and her newborn showed that oligoclonal banding patterns were superimposable. Our data indicated that: 1) the IgG forming OB in the newborn's serum derive from a passive filtration from mother's serum; 2) the presence of OB seems to be an unfavourable prognostic feature in infants at risk for HIV-1 infection.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Infant; Risk; Viral Core Proteins; Humans; Acquired Immunodeficiency Syndrome; Infant, Newborn; Infant, Newborn, Diseases; HIV Core Protein p24; Gene Products, gag; HIV-1
Elenco autori:
G.V. Martino, L.M. Grimaldi, L. Moiola, A. Castagna, R. Novati, A. D'Arminio-Monforte, E. Massironi, P. Marchisio, R. Tornaghi, N. Principi
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