HIV-1 reverse transcriptase codon 215 mutation and clinical outcome in children treated with zidovudine
Articolo
Data di Pubblicazione:
1994
Citazione:
HIV-1 reverse transcriptase codon 215 mutation and clinical outcome in children treated with zidovudine / N. Principi, P. Marchisio, M. P. De Pasquale, E. Massironi, R. Tornaghi, T. Vago. - In: AIDS RESEARCH AND HUMAN RETROVIRUSES. - ISSN 0889-2229. - 10:6(1994 Jun), pp. 721-726.
Abstract:
In HIV-infected adults prolonged monotherapy with zidovudine may be associated with the appearance of HIV strains with decreased zidovudine sensitivity, owing to specific mutations in the reverse transcriptase (RT) gene, and this has been suggested to be a reason for reduced zidovudine efficacy. This study was undertaken to determine the appearance of mutation at codon 215 of the RT gene in proviral DNA from PBMCs in HIV-infected children.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Humans; Drug Resistance, Microbial; Zidovudine; Child; HIV-1; Child, Preschool; Infant; RNA-Directed DNA Polymerase; DNA Probes; Base Sequence; Prospective Studies; HIV Infections; Treatment Outcome; Molecular Sequence Data; HIV Reverse Transcriptase; Mutation
Elenco autori:
N. Principi, P. Marchisio, M. P. De Pasquale, E. Massironi, R. Tornaghi, T. Vago
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