Hyperresponsiveness to dietary cholesterol in inbred rabbits is not associated with enhanced reduction in binding of beta-VLDL to liver membranes
Articolo
Data di Pubblicazione:
1992
Citazione:
Hyperresponsiveness to dietary cholesterol in inbred rabbits is not associated with enhanced reduction in binding of beta-VLDL to liver membranes / G. W. Meijer, A. C. Beynen, M. R. Lovati, C. Manzoni, L. F. Van Zutphen, C. R. Sirtori. - In: JOURNAL OF NUTRITION. - ISSN 0022-3166. - 122:4(1992 Apr), pp. 931-939.
Abstract:
In two inbred strains of rabbits with high or low response of serum cholesterol to dietary cholesterol, binding of rabbit beta-VLDL to hepatic membrane preparations was determined. The objective was to test the hypothesis that after cholesterol feeding, hyperresponders show a more dramatic reduction in hepatic apolipoprotein (apo) B/E receptors, which may explain the development of the high degree of cholesterolemia in these animals. The number of hepatic high affinity receptors for beta-VLDL in hyperresponders fed a diet without added cholesterol was, on average, 20% lower than that in hyporesponders. After the addition of increasing amounts of cholesterol to the diet, liver cholesterol concentrations were elevated to a greater extent in hyper- than in hyporesponsive rabbits. Liver free cholesterol concentrations were negatively associated with maximal binding of beta-VLDL to liver membranes. With increasing liver free cholesterol concentrations, maximal binding was less effectively depressed in hyper- than hyporesponders. We conclude that in the inbred strains of rabbits, hyperresponsiveness to dietary cholesterol is not caused by enhanced depression of hepatic apo B/E receptors.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
apo B/E receptors; hypercholesterolemia; hyperresponders; hyporesponders; rabbits
Elenco autori:
G. W. Meijer, A. C. Beynen, M. R. Lovati, C. Manzoni, L. F. Van Zutphen, C. R. Sirtori
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