Data di Pubblicazione:
1999
Citazione:
Novel adrenoceptor antagonists with a tricyclic pyrrolodipyridazine skeleton / D. barlocco, G. Cignarella, F. Montesano, A. Leonardi, M. Mella, L. Toma. - In: JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0022-2623. - 42:1(1999), pp. 173-177.
Abstract:
A still unknown tricyclic heterocyclic system (5) was synthesized from 6-hydroxy-2-methylpyridazin-3-one and its structure identified as 2,8- dichloro-6-methylpyrrolo[1,2-b:3,4-d']dipyridazin-5(6H)-one by spectroscopic investigations. Selective condensation of 5 with 2-[4-(2-substituted- phenyl)piperazin-1-yl]ethylamine gave the 2-arylpiperazinylethylamino-8- chloro derivatives 6a-c, which were investigated in binding studies toward the three α1-adrenergic and 5-HT(1A)-serotonergic receptor subtypes. They displayed high potency on all the assays and some selectivity for α(1a) and α(1d) subtypes.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
D. barlocco, G. Cignarella, F. Montesano, A. Leonardi, M. Mella, L. Toma
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