Increased jejunal intraepithelial lymphocytes bearing gamma/delta T-cell receptor in dermatitis herpetiformis
Articolo
Data di Pubblicazione:
1992
Citazione:
Increased jejunal intraepithelial lymphocytes bearing gamma/delta T-cell receptor in dermatitis herpetiformis / M. Vecchi, L. Crosti, E. Berti, D. Agape, A. Cerri, R. De Franchis. - In: GASTROENTEROLOGY. - ISSN 0016-5085. - 102:5(1992 May), pp. 1499-1505.
Abstract:
T-cell receptor 1 (gamma/delta) expression was studied in 19 jejunal or duodenal specimens from patients with dermatitis herpetiformis and in 16 jejunal or duodenal specimens showing normal histology. In normal specimens, gamma/delta+ cells represented 10.8% of intraepithelial CD3+ lymphocytes. Around 50% of these cells were recognized by the A13 monoclonal antibody, which detects products of the V gamma 1/V delta 1 gene rearrangement and the non-disulfide-linked form of T-cell receptor 1. The remaining 50% reacted with the BB3 monoclonal antibody, which recognizes products of the V gamma 9/V delta 2 rearrangement and the disulfide-linked form of receptor. Very few gamma/delta+ cells were observed in the lamina propria. In jejunal specimens from patients with dermatitis herpetiformis, a significant increase in the prevalence of gamma/delta+ intraepithelial lymphocytes was observed (P less than 0.001). This finding was largely accounted for by an increase in those cells recognized by the A13 monoclonal antibody, thus possibly expressing the V gamma 1/V delta 1 rearrangement and the nondisulfide-linked form of receptor. These data suggest that similar pathogenetic mechanisms may be active in determining the jejunal damage in celiac disease and dermatitis herpetiformis.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Antigens, Differentiation, T-Lymphocyte; Animals; Gene Rearrangement, delta-Chain T-Cell Antigen Receptor; Antigens, CD8; Antigens, CD3; Jejunum; Humans; Receptors, Antigen, T-Cell, gamma-delta; Receptors, Antigen, T-Cell; Mice; Dermatitis Herpetiformis; T-Lymphocytes
Elenco autori:
M. Vecchi, L. Crosti, E. Berti, D. Agape, A. Cerri, R. De Franchis
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