Modulation of opioid system in C57 mice after repeated treatment with morphine and naloxone : Biochemical and behavioral correlates
Articolo
Data di Pubblicazione:
1984
Citazione:
Modulation of opioid system in C57 mice after repeated treatment with morphine and naloxone : Biochemical and behavioral correlates / N. Brunello, A. Volterra, A.M. Di Giulio, V. Cuomo, G. Racagni. - In: LIFE SCIENCES. - ISSN 0024-3205. - 34:17(1984), pp. 1669-1678. [10.1016/0024-3205(84)90638-6]
Abstract:
C57 BL/6J (C57) mice display a particular pattern of responses following morphine administration, such as a rapid development of tolerance to the pharmacological action of the opiate and an increase in locomotor activity after a single injection of the drug. We have measured met-enkephalin content and the responsiveness of different opiate receptors after repeated administration of morphine and naloxone. Prolonged morphine administration changed neither met-enkephalin levels, nor the density of opiate receptors in mice brain. In contrast repeated administration of the opiate antagonist naloxone, produced a marked increase in the number of 3H-DHM and 3H-DADLE binding sites in striatum and brainstem without modifying met-enkephalin concentrations. Behavioral studies have indicated that the morphine-induced increase in locomotor activity is enhanced in naloxone pretreated mice, thus suggesting a possible correlation between the behavioral response to morphine in C57 mice and the higher number of opiate receptors in the striatum
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
N. Brunello, A. Volterra, A.M. Di Giulio, V. Cuomo, G. Racagni
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