Diastereo- and enantioselective synthesis of 1,2-diols by V(II)-promoted pinacol cross coupling
Articolo
Data di Pubblicazione:
1991
Citazione:
Diastereo- and enantioselective synthesis of 1,2-diols by V(II)-promoted pinacol cross coupling / R. Annunziata, M. Benaglia, M. Cinquini, F. Cozzi, P. Giaroni. - In: TETRAHEDRON. - ISSN 0040-4020. - 47:30(1991), pp. 5737-5758.
Abstract:
The V(II) promoted pinacol cross coupling of a chiral aromatic aldehyde with chiral aliphatic aldehydes occurs to afford syn diols in up to 91:9 diastereoisomeric ratio and up to 84% enantiomeric excess. The pinacol coupling of (S)-lactaldehyde and (R)-glyceraldehyde derivatives has also been studied and matching and mis-matching pairs have been identified. The stereochemistry of the products was established by correlation. The sense and degree of stereoselection is discussed.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
R. Annunziata, M. Benaglia, M. Cinquini, F. Cozzi, P. Giaroni
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