Data di Pubblicazione:
2012
Citazione:
Reactions and enzymes in the metabolism of drugs and other xenobiotics / B. Testa, A. Pedretti, G. Vistoli. - In: DRUG DISCOVERY TODAY. - ISSN 1359-6446. - 17:11/12(2012 Jun), pp. 549-560.
Abstract:
In this article, we offer an overview of the compared quantitative importance of biotransformation reactions in the metabolism of drugs and other xenobiotics, based on a meta-analysis of current research interests. Also, we assess the relative significance the enzyme (super)families or categories catalysing these reactions. We put the facts unveiled by the analysis into a drug discovery context and draw some implications. The results confirm the primary role of cytochrome P450-catalysed oxidations and UDP-glucuronosyl-catalysed glucuronidations, but they also document the marked significance of several other reactions. Thus, there is a need for several drug discovery scientists to better grasp the variety of drug metabolism reactions and enzymes and their consequences.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
matabolism; meta-analysis; classification of metabolic reactions
Elenco autori:
B. Testa, A. Pedretti, G. Vistoli
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