Preliminary evaluation of two fluorescence imaging methods for the detection and the delineation of basal cell carcinomas of the skin
Articolo
Data di Pubblicazione:
2000
Citazione:
Preliminary evaluation of two fluorescence imaging methods for the detection and the delineation of basal cell carcinomas of the skin / S. Andersson-Engels, G. Canti, R. Cubeddu, C. Eker, C. af Klinteberg, A. Pifferi, K. Svanberg, S. Svanberg, P. Taroni, G. Valentini, I. Wang. - In: LASERS IN SURGERY AND MEDICINE. - ISSN 0196-8092. - 26:1(2000), pp. 76-82. [10.1002/(SICI)1096-9101(2000)26:1<76::AID-LSM11>3.0.CO;2-4]
Abstract:
Fluorescence techniques can provide powerful noninvasive means for medical diagnosis, based on the detection of either endogenous or exogenous fluorophores. The fluorescence of delta-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) has already shown promise for the diagnosis of tumors. The aim of the study was to investigate the localization of skin tumors after the topical application of ALA, by detecting the PpIX fluorescence either in the spectral or in the time domain. STUDY DESIGN/MATERIALS N AND METHODS: Two fluorescence imaging systems were used to identify basal cell carcinomas of the skin in humans, after topical application of 20% ALA ointment. Both systems rely on the comparison between the exogenous and the endogenous fluorescence, performed either in the spectral domain or in the time domain. The first system works by using three images acquired through different spectral filters, whereas the second one measures the spatial map of the average fluorescence lifetime of the sample.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Photosensitizing Agents; Spectrometry, Fluorescence; Aged, 80 and over; Humans; Adult; Aged; Carcinoma, Basal Cell; Skin Neoplasms; Protoporphyrins; Male; Aminolevulinic Acid
Elenco autori:
S. Andersson Engels, G. Canti, R. Cubeddu, C. Eker, C. af Klinteberg, A. Pifferi, K. Svanberg, S. Svanberg, P. Taroni, G. Valentini, I. Wang
Link alla scheda completa: