Human milk oligosaccharides: an enzymatic protection step simplifies the synthesis of 3 '- and 6 '-O-sialyllactose and their analogues
Articolo
Data di Pubblicazione:
2002
Citazione:
Human milk oligosaccharides: an enzymatic protection step simplifies the synthesis of 3 '- and 6 '-O-sialyllactose and their analogues / A. Rencurosi, L. Poletti, M. Guerrini, G. Russo, L. Lay. - In: CARBOHYDRATE RESEARCH. - ISSN 0008-6215. - 337:6(2002), pp. 473-483.
Abstract:
We describe a chemo-enzymatic synthesis of 3'- and 6'-O-sialyllactose, two trisaccharides occurring in the 'acidic fraction' of the human milk oligosaccharides and endowed with potential antiadhesive activity. The key step is the highly regioselective 6'-O-acylation of benzyllactoside, which gave access to suitably protected lactose building blocks to be used as acceptors in the sialylation reaction. Moreover, the synthesis of the carboxymethyl and sulfo analogues of the title compounds is reported. (C) 2002 Elsevier Science Ltd. All rights reserved.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Benzyllactoside; Enzymatic 6′-O-acylation; Human milk oligosaccharides
Elenco autori:
A. Rencurosi, L. Poletti, M. Guerrini, G. Russo, L. Lay
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