COX-1 and COX-2 inhibition in horse blood by phenylbutazone, flunixin, carprofen and meloxicam: an in vitro analysis
Articolo
Data di Pubblicazione:
2005
Citazione:
COX-1 and COX-2 inhibition in horse blood by phenylbutazone, flunixin, carprofen and meloxicam: an in vitro analysis / C. Beretta, G. Garavaglia, M. Cavalli. - In: PHARMACOLOGICAL RESEARCH. - ISSN 1043-6618. - 52:4(2005), pp. 302-306.
Abstract:
We report on the inhibitory activity of the NSAIDs meloxicam, carprofen, phenylbutazone and flunixin, on blood cyclooxygenases in the horse using in vitro enzyme-linked assays. As expected, comparison of IC50 indicated that meloxicam and carprofen are more selective inhibitors of COX-2 than phenylbutazone and flunixin; meloxicam was the most advantageous for horses of four NSAIDs examined. However at IC80, phenylbutazone (+134.4%) and flunixin (+29.7%) had greater COX-2 selectivity than at IC50, and meloxicam (-41.2%) and carprofen (-12.9%) had lower COX-2 selectivity than at IC50. We therefore propose that the selectivity of NSAIDs should be assessed at the 80% as well as 50% inhibition level.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Horse blood cyclooxygenases; NSAIDs; Selectivity of inhibition
Elenco autori:
C. Beretta, G. Garavaglia, M. Cavalli
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