Data di Pubblicazione:
1977
Citazione:
Synthesis of cholestanes containing an oxygenated 14α-methyl group / M. Anastasia, A. Fiecchi, G. Cighetti, G. Galli. - In: JOURNAL OF THE CHEMICAL SOCIETY. PERKIN TRANSACTIONS. I. - ISSN 0300-922X. - :6(1977), pp. 700-702.
Abstract:
Hydrocyanation of 3β-acetoxy-5α-cholest-8(14)-en-7-one has been achieved by reaction with diethylaluminium cyanide. The resulting 14α-cyano-7-ketone was reduced with sodium borohydride to the 7α-hydroxy-compound, the methanesulphonate of which, when refluxed in collidine, gave 3β-acetoxy-5α-cholest-7-ene-14α-carbonitrile. Reduction of the cyano-group with di-isobutylaluminium hydride afforded 3β-hydroxy-5α-cholest-7-ene-14α-carbaldehyde, which was transformed with lithium aluminium hydride into 14α-hydroxymethyl-5α-cholest-7-en-3β-ol.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
cholestane derivative ; nitrile, article ; synthesis ; technique, Cholestenes ; Cholestenones ; cholest 4 en 3 one ; Cholestenones
Elenco autori:
M. Anastasia, A. Fiecchi, G. Cighetti, G. Galli
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