Effect of caseinphosphopeptides on inhibition of calcium intestinal absorption due to phosphate
Articolo
Data di Pubblicazione:
2001
Citazione:
Effect of caseinphosphopeptides on inhibition of calcium intestinal absorption due to phosphate / D. Erba, S. Ciappellano, G. Testolin. - In: NUTRITION RESEARCH. - ISSN 0271-5317. - 21:4(2001), pp. 649-656. [10.1016/S0271-5317(01)00280-9]
Abstract:
Caseinphosphopeptides (CPPs) are peptides resulting from enzyme digestion of whole casein,
characterized by the presence of an aminoacid cluster, negatively charged at physiological intestinal
pH, that binds cations. The aim of the present study was to compare Ca absorption through the everted
small intestine of rats from CaCl2 or Ca-CPPs solutions, in absence of inorganic phosphate (Pi) or
when two ratios between Ca and Pi occur. Secondly, it was evaluated whether the ion absorption could
be affected by the fatty acid pattern of enterocyte membrane. Results showed that in the absence of
Pi, Ca transport from CaCl2 was higher than from Ca-CPPs solutions. However, when Pi was added
to the CaCl2 solution, Ca absorption decreased by 90% (Ca:Pi = 1:1) and 97% (Ca:Pi = 1:2). On the
contrary, when Pi was added to the Ca-CPPs solution, Ca transport decreased only by 40% (Ca:Pi =
1:1) and 60% (Ca:Pi = 1:2). The enrichment of enterocyte membrane with n-3 fatty acids (fish oil
diet) compared to control diet did not modify the effect of CPPs on Ca transport in ileum of rats. These
findings demonstrate that CPPs can limit the inhibitory effect of phosphate on Ca availability and
increase Ca transport across the distal small intestine. This action could be of nutritional relevance
especially when the dietary intake of this mineral is lower than the recommended level or there is an
unbalanced ratio Ca/Pi in diet.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Ca absorption; Caseinphosphopeptides; Phosphate
Elenco autori:
D. Erba, S. Ciappellano, G. Testolin
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