Data di Pubblicazione:
1996
Citazione:
Synthesis and antimicrobial activities of 4-purpuromycin derivatives / A. Trani, C. Dallanoce, P. Ferrari, B. Goldstein, F. Ripamonti, R. Ciabatti. - In: IL FARMACO. - ISSN 0014-827X. - 51:7(1996), pp. 503-512.
Abstract:
Purpuromycin (1) is a natural antibiotic with a broad spectrum of
activity encompassing bacteria, fungi and protozoa. A new series of
derivatives of 1 was prepared by the modification or replacement of the
C-4 hydroxyl group. The physico-chemical characteristics and the in
vitro antimicrobial activity of these new semisynthetic purpuromycin
derivatives are reported. Attachment of a variety of bulky groups to the
C-4 hydroxyl group as well as acylation or mesylation of 1 gave
derivatives with significantly reduced antifungal activity, while the
antimicrobial activity of these derivatives against Gram-positive and
Gram-negative bacteria was only slightly decreased. All compounds were
inactive against Escherichia coli. The C-4 epimers showed different in
vitro activity as compared with those having the natural configuration,
particularly against fungi.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
A. Trani, C. Dallanoce, P. Ferrari, B. Goldstein, F. Ripamonti, R. Ciabatti
Link alla scheda completa: