Data di Pubblicazione:
1996
Citazione:
Synthesis and biological evaluation of new fragments from kirromycin
antibiotic / P. Tavecchia, A. Marazzi, C. Dallanoce, A. Trani, I. Ciciliato, P. Ferrari, E. Selva, R. Ciabatti. - In: JOURNAL OF ANTIBIOTICS. - ISSN 0021-8820. - 49:12(1996), pp. 1249-1257. [10.7164/antibiotics.49.1249]
Abstract:
New N-acyl derivatives of 1-N-desmethyl goldinamine were obtained from
degradation of kirromycin. Periodate-oxidation of these derivatives
provided new aldehydic fragments that were further elaborated. Both
N-phenyl ureido and N-phthalimido derivatives of 1-N-desmethyl
goldinamine are able to inhibit bacterial protein synthesis in cell-free
assay and are active against whole microorganisms, although with lower
potency than kirromycin. The derivatives from the aldehydic fragments
are totally inactive.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
P. Tavecchia, A. Marazzi, C. Dallanoce, A. Trani, I. Ciciliato, P. Ferrari, E. Selva, R. Ciabatti
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