Data di Pubblicazione:
1986
Citazione:
Pharmacokinetics of two new oral formulations of ibuprofen / C. Benvenuti, V. Cancellieri, V. Gambaro, F. Lodi, E. Marozzi, C. Scaroni. - In: INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY THERAPY AND TOXICOLOGY. - ISSN 0174-4879. - 24:6(1986), pp. 308-312.
Abstract:
Two new formulations of ibuprofen (I) [15687-27-1] were studied in 600 mg coated tablets and granules, to allow an easier adjustment of its daily dosage now higher than in the past. Six healthy volunteers (3 males and 3 females, mean age 32.6 yr) took part in a 6 × 6 Latin Square single dose pharmacokinetic study comparing 6 oral formulations of I: 600 mg coated tablets, 300, 400 and 600 mg resinated granules, and 300 and 400 mg sugar-coated tablets available on the market as Brufen. A correlation between dose and the area under the blood concn.-time curve was obsd. The availability of I was similar irresp. of whether it is given in the form of granules or in tablets. The short half-life and the widespread use of I give an acceptable range of safety to these new formulations.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
C. Benvenuti, V. Cancellieri, V. Gambaro, F. Lodi, E. Marozzi, C. Scaroni
Link alla scheda completa: