Data di Pubblicazione:
1991
Citazione:
Androgen metabolism in the brain / L. Martini, R. C. Melcangi. - In: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. - ISSN 0960-0760. - 39:5B(1991 Nov), pp. 819-828.
Abstract:
The paper summarizes the most recent views on androgen metabolism in the brain. In particular it will be shown that: (1) the enzyme 5 alpha-reductase is particularly concentrated in the white matter; (2) 5 alpha-reductase is also present in the myelin; 5 alpha-reductase is present in higher concentrations in neurons (isolated or cultured) that in glial cells (astrocytes and oligodendrocytes); (4) only neurons possess the capability of aromatizing androgens to estrogens; and (5) a possible role of steroid metabolism in the control of the process of myelinogenesis is suggested.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Rats; Animals; Aromatase; Neuroglia; Neurons; Brain; Myelin Sheath; 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Male; Androgens
Elenco autori:
L. Martini, R. C. Melcangi
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