Data di Pubblicazione:
1985
Citazione:
Anti-MAG antibody and antibody complexes: detection by radioimmunoassay / E. Nobile-Orazio, C. McIntosh, N. Latov. - In: NEUROLOGY. - ISSN 0028-3878. - 35:7(1985 Jul), pp. 988-92-992.
Abstract:
A radioimmunoassay (RIA) for measuring isotype-specific antibodies to the myelin-associated glycoprotein (MAG) was developed using radiolabeled CNS MAG in a double-antibody precipitation system. Anti-MAG activity was detected by RIA only in patients with neuropathy and anti-MAG M proteins. Anti-MAG IgM or IgG antibodies were not detected in serum of patients with Guillain-Barré syndrome, chronic relapsing polyneuritis, or multiple sclerosis (MS). Some patients with anti-MAG IgM M proteins also had complexes of IgG or IgA bound to the M protein. In one patient, anti-CNS MAG activity was detected by RIA, but not by ELISA or immunoblot. Anti-MAG antibody activity in patients with neuropathy seems to be isotypically restricted, and there is no evidence for antibody reactivity to MAG in other demyelinating diseases.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Immunoglobulin A; Myelin-Associated Glycoprotein; Myelin Proteins; Peripheral Nervous System Diseases; Humans; Immunoglobulin G; Central Nervous System Diseases; Immunosorbent Techniques; Radioimmunoassay; Immunoglobulin M; Antibodies, Anti-Idiotypic
Elenco autori:
E. Nobile-Orazio, C. Mcintosh, N. Latov
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