Data di Pubblicazione:
1996
Citazione:
Anti-GD1a ganglioside antibodies in peripheral motor syndromes / M. Carpo, E. Nobile-Orazio, N. Meucci, M. Gamba, S. Barbieri, S. Allaria, G. Scarlato. - In: ANNALS OF NEUROLOGY. - ISSN 0364-5134. - 39:4(1996 Apr), pp. 539-43-543.
Abstract:
High titers of anti-GD1a antibodies have been found in patients with Guillain-Barre syndrome or motor neuropathy. To determine the possible diagnostic relevance of these antibodies, we measured serum anti-GD1a IgG and IgM antibodies by enzyme-linked immunosorbent assay in 195 patients with different motor syndromes and in 335 control subjects. Moderately high antibody titers (1/1,280-1/5,120) were occasionally found in patients with chronic inflammatory demyelinating polyneuropathy (5%), multifocal motor neuropathy (18%), lower motor neuron disease (3.8%), or amyotrophic lateral sclerosis (1.8%) and in immunological control subjects (1.2%), while titers of 1/20,480 or higher were only found in 2 patients with Guillain-Barre syndrome (IgG in both) and 2 with motor neuropathy and IgM lambda monoclonal gammopathy improving with immunotherapy. In both motor neuropathy patients and the Guillain-Barre syndrome patient who were retested during recovery, anti-GD1a titers decreased concomitantly with clinical improvement. High anti-GD1a antibody titers may be found in several motor syndromes but only markedly increased anti-GD1a titers are strictly associated with potentially treatable dysimmune neuropathies.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Demyelinating Diseases; Polyradiculoneuropathy; Humans; Aged; Gangliosides; Antibodies; Neuromuscular Diseases; Peripheral Nervous System Diseases; Immunoglobulin G; Enzyme-Linked Immunosorbent Assay; Chromatography, Thin Layer; Middle Aged; Female; Immunoglobulin M
Elenco autori:
M. Carpo, E. Nobile-Orazio, N. Meucci, M. Gamba, S. Barbieri, S. Allaria, G. Scarlato
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