Data di Pubblicazione:
2002
Citazione:
Safety considerations for statins / C. Bolego, R. Baetta, S. Bellosta, A. Corsini, R. Paoletti. - In: CURRENT OPINION IN LIPIDOLOGY. - ISSN 0957-9672. - 13:6(2002 Dec), pp. 637-644.
Abstract:
The hydroxymethyl glutaryl coenzyme A reductase inhibitors or statins offer important benefits for the large populations of individuals at high risk for coronary heart disease. These drugs have a good safety profile. Nevertheless, differences in physicochemical and pharmacokinetic properties between statins may translate into significant differences in long-term safety. This review focuses on long-term adverse effects related to statin use, namely hepatotoxicity and myopathy. Moreover, the most common drugs used in combination with statins in long-term therapies are analyzed in terms of possible drug/drug interactions affecting the safety of statins.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Drug interactions; Myopathy; Pharmacokinetics; Rhabdomyolysis
Elenco autori:
C. Bolego, R. Baetta, S. Bellosta, A. Corsini, R. Paoletti
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