Data di Pubblicazione:
1994
Citazione:
Influence of opioid system on behavioral sensitization induced by cocaine in the rat / M. Sala, D. Braida, M. Colombo, F. Terzi, M.P. Leone, E. Gori. - In: REGULATORY PEPTIDES. - ISSN 0167-0115. - 53:Suppl.1(1994), pp. 199-200. ((Intervento presentato al 24. convegno International Narcotics Research Conference (INRC): Towards a Molecular Basis in Opioid Research tenutosi a Skode, Sweden nel 1993.
Abstract:
In rats, repeated daily ip administrations of a low dose (10 mg/kg) of cocaine HCl (COC) produced enhanced locomotor activity; a higher dose (50 mg/kg) led to seizures (pharmacological kindling). Daily pretreatment with naltrexone (NTX)(2 mg/kg/sc), injected 15 min prior to COC, completely antagonized COC-induced motor and convulsant activity, except on the first day when a potentiation of seizures was observed. Using the same treatment schedule, COC 50 mg/kg failed to induce sensitization to the well known local anesthetic properties evaluated through the loss of abdominal tone; this effect was not reversed by NTX pretreatment. These findings provide further evidence of the modulatory role of the opiate system on cocaine sensitization.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
M. Sala, D. Braida, M. Colombo, F. Terzi, M.P. Leone, E. Gori
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