ANTISENSE OLIGONUCLEOTIDE BLOCKS PROGESTERONE-INDUCED LORDOSIS BEHAVIOR IN OVARIECTOMIZED RATS
Articolo
Data di Pubblicazione:
1993
Citazione:
ANTISENSE OLIGONUCLEOTIDE BLOCKS PROGESTERONE-INDUCED LORDOSIS BEHAVIOR IN OVARIECTOMIZED RATS / G. Pollio, P. Xue, M. Zanisi, A. Nicolin, A. Maggi. - In: MOLECULAR BRAIN RESEARCH. - ISSN 0169-328X. - 19:1-2(1993 Jul), pp. 135-139. [10.1016/0169-328X(93)90158-L]
Abstract:
Antisense oligonucleotides were utilized to interfere with the synthesis of progesterone receptor. A specific aODN was shown to decrease significantly the levels of PR in the T47D cell line known to express the PR gene. The molecule described was proved to be effective in hindering the effect of progesterone on target gene expression in T47D cells. The aODN was then utilized in an in vivo study to test its efficacy on the female rat sex behavior. Its injection in the ventromedial hypotalamus significantly inhibited the estrous responsiveness induced by progesterone. This study provides a clear demonstration of the full involvement of PR in the manifestation of lordosis behavior and demonstrates the activity of an aODN as antiprogestative.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Antiprogestin; Antisense oligonucleotide; Progesterone receptor; Sexual behavior
Elenco autori:
G. Pollio, P. Xue, M. Zanisi, A. Nicolin, A. Maggi
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