Effect of centrally administered atropine and pirenzepine on radial arm maze performance in the rat
Articolo
Data di Pubblicazione:
1991
Citazione:
Effect of centrally administered atropine and pirenzepine on radial arm maze performance in the rat / M. Sala, D. Braida, P. Calcaterra, M.P. Leone, F.A. Comotti, S. Gianola, E. Gori. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - 194:1(1991), pp. 45-49. [10.1016/0014-2999(91)90122-7]
Abstract:
The effect of two anticholinergic drugs administered intracerebroventricularly on acquisition of an 8-arm radial maze task was examined in the rat. Increasing doses of atropine (1, 4.5, 22.5, 45 μg/rat) and pirenzepine (4.5, 15, 60, 90 μg/rat) significantly impaired performance in the working-memory components of the task. For both drugs this impairment was linearly related to the log of the administered doses and log-dose-response relationships were parallel. The regression lines calculated for each parameter for both drugs were parallel to each other, thus allowing us to calculate the potency of atropine versus pirenzepine: atropine was 5.4 times more potent than pirenzepine for correct arm entries, 10 times more potent for the number of errors and 4 times more potent for the total time taken to complete the task. The relevance of M1 and M2 subtype central acetylcholine receptors in cognitive processes is discussed.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
(Intracerebroventricular administration); Atropine; Pirenzepine; Radial maze
Elenco autori:
M. Sala, D. Braida, P. Calcaterra, M.P. Leone, F.A. Comotti, S. Gianola, E. Gori
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