Data di Pubblicazione:
1992
Citazione:
FURTHER CHARACTERIZATION OF THE SOLID FORMS OF IOPANOIC ACID AND ITS
ENANTIOMERS / D. Pitré, M. De Amici, M. Colombo, G.G. Gallo, M. Nebuloni. - In: ARCHIV DER PHARMAZIE. - ISSN 0365-6233. - 325:7(1992), pp. 385-388.
Abstract:
The enantiomers of iopanoic acid were purified by crystallization and
characterized by optical rotation, DSC, IR spectra, X-ray powder
diffraction, and chiral HPLC. (-R)-enantiomer: {[alpha]20D =
-6.1-degrees, mp. = 165.4-degrees-C; (+S)-enantiomer: [alpha]20D = +
6.2-degrees, mp. = 165.6-degrees-C. The IR spectra and X-ray patterns
are fingerprints. Chiral HPLC (isocratic method, mobile phase:
ethanol/nhexane, 2/98 with 0.5\% acetic acid) gave a resolution = 0.98
and a 99.6\% recovery.
From X-ray and thermal analyses the racemate Form I, mp. =
153.8-degrees-C, resulted to be a racemic compound. The binary phase
diagram between the enantiomers and the racemic compound was constructed
from the phase transition temp. obtained by DSC heating curves of
appropriate mixtures. At a given enantiomer ratio (71/29) a eutectic
compound, mp. = 144.7-degrees-C, is formed. In the range 88-100\% a
solid solution between the components is observed.}
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
D. Pitré, M. De Amici, M. Colombo, G.G. Gallo, M. Nebuloni
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