Data di Pubblicazione:
1993
Citazione:
SYNTHESIS AND MUSCARINIC ACTIVITY OF SOME MUSCARONE ANALOGS / C. De Micheli, M. De Amici, E. Grana, F. Zonta, M. Giannella, A. Piergentili. - In: IL FARMACO. - ISSN 0014-827X. - 48:10(1993), pp. 1333-1348.
Abstract:
The synthesis of some muscarone analogs has been accomplished and their
muscarinic activity has been assayed in three in vitro functional tests.
The results of such an investigation put in evidence the active role
played by the methylene moiety, placed exocyclic to the pentaatomic
ring, on the interaction of the ligands with the different muscarinic
receptor subtypes. Worth noting is the ileum-atria selectivity displayed
by methylene derivative 7.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
C. De Micheli, M. De Amici, E. Grana, F. Zonta, M. Giannella, A. Piergentili
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