Effects of dilazep on human platelets and rat vascular tissue: in vitro studies on platelet aggregation, and arachidonic acid oxidation
Articolo
Data di Pubblicazione:
1983
Citazione:
Effects of dilazep on human platelets and rat vascular tissue: in vitro studies on platelet aggregation, and arachidonic acid oxidation / S. Colli, P. Maderna, G. Morazzoni, C. Speroni, E. Tremoli. - In: PHARMACOLOGICAL RESEARCH COMMUNICATIONS. - ISSN 0031-6989. - 15:6(1983 Jun), pp. 593-602.
Abstract:
The "in vitro" effects of Dilazep on platelet aggregation and arachidonic acid oxidation in platelets and vessel wall were studied. Dilazep exerted a clearcut inhibitory effect on platelet aggregation induced by several stimuli. In addition, the compound completely suppressed malondialdehyde production by platelets elicited by collagen and thrombin, in a dose-dependent fashion. The evaluation of Dilazep effects on the in vitro release of prostacyclin-like material by rat aortic tissue did not provide any indication about an interference of the drug on the generation of endogenous antiaggregatory material.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Animals; Aorta; Humans; Blood Vessels; Dilazep; Rats; Arachidonic Acids; Oxidation-Reduction; Platelet Aggregation; Blood Platelets; Azepines; Epoprostenol; Arachidonic Acid; Male; Malondialdehyde
Elenco autori:
S. Colli, P. Maderna, G. Morazzoni, C. Speroni, E. Tremoli
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