Testosterone metabolites in patients reduce the levels of very long chain fatty acids accumulated in X-adrenoleukodystrophic fibroblasts
Articolo
Data di Pubblicazione:
2000
Citazione:
Testosterone metabolites in patients reduce the levels of very long chain fatty acids accumulated in X-adrenoleukodystrophic fibroblasts / A. Petroni, N. Papini, M. Blasevich, V. Magnaghi, I. Cavarretta, C. Galli, R.C. Melcangi. - In: NEUROSCIENCE LETTERS. - ISSN 0304-3940. - 289:2(2000 Aug 04), pp. 139-142.
Abstract:
Testosterone metabolites (dihydrotestosterone, DHT) and 5 alpha-androstan-3 alpha,17 beta-diol (3 alpha-diol), but not testosterone itself, were shown to reduce the levels of very long chain fatty acids which accumulate in cultured skin fibroblasts from X-adrenoleukodystrophic patients (X-ALD). In addition, in X-ALD fibroblasts, testosterone is less actively converted into DHT vs. controls (skin fibroblasts retrieved from normal subjects) whereas the additional conversion of DHT to the final product 3 alpha-diol is enhanced. This is the first report of altered testosterone metabolism in X-ALD fibroblasts and of the effects of androgens in lowering the abnormal accumulation of very long chain fatty acids in this type of cells.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
3α-Diol; 5α-Androstan-17β-ol-3-one; 5α-Androstan-3α,17β-diol; Dihydrotestosterone; Testosterone; Very long chain fatty acids; X-adrenoleukodystrophy
Elenco autori:
A. Petroni, N. Papini, M. Blasevich, V. Magnaghi, I. Cavarretta, C. Galli, R.C. Melcangi
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