Synthesis and binding affinity of new muscarinic ligands structurally related to oxotremorine
Articolo
Data di Pubblicazione:
1997
Citazione:
Synthesis and binding affinity of new muscarinic ligands structurally
related to oxotremorine / P. Conti, C. Dallanoce, M. De Amici, C. De Micheli, B. Ebert. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 7:8(1997), pp. 1033-1036.
Abstract:
The synthesis and radioligand binding assays of a group of muscarinic
ligands related to oxotremorine are reported. The new compounds
displayed binding affinities comparable to those of the parent molecule
with the exception of the trimethylammonium salt 6, which behaved as a
fill muscarinic agonist and showed a pronounced selectivity for M-2
versus M-1 muscarinic receptor subtypes. (C) 1997 Elsevier Science Ltd.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
P. Conti, C. Dallanoce, M. De Amici, C. De Micheli, B. Ebert
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