Regulation of NMDA receptor subunit messenger RNA levels in the rat brain following acute and chronic exposure to antipsychotic drugs
Articolo
Data di Pubblicazione:
1997
Citazione:
Regulation of NMDA receptor subunit messenger RNA levels in the rat brain following acute and chronic exposure to antipsychotic drugs / M.A. Riva, F. Tascedda, E. Lovati, G.A. Racagni. - In: MOLECULAR BRAIN RESEARCH. - ISSN 0169-328X. - 50:1-2(1997), pp. 136-142.
Abstract:
Based on anatomical and biochemical observations a role of glutamate in schizophrenia has been postulated. in the present work we have investigated the gene expression for two families of NMDA receptor subunits (NR-I and NR-2) following acute and chronic treatment with typical (haloperidol) and atypical (clozapine) antipsychotic drug (APD) in rats. A single injection of the two drugs elicited a significant increase in the mRNA levels of NR-2B in the nucleus accumbens, whereas only haloperidol was able to elevate NR-2A and NR-2B in the hippocampus. Following a 21 day treatment, significant differences in the regulatory pattern of NMDA-R subunits were observed. Haloperidol increased their mRNA levels in striatum whereas clozapine. consistent with its relatively weaker influence on nigro-striatal dopamine function, did not change the expression of NR subunits in this region. Both APD's were able to decrease the expression of NR-2 subunits in the hypothalamus, but only clozapine was capable of reducing NR-2C in frontal cortex and accumbens. The regulation of NMDA-R subunits in specific brain regions may represent a novel and important mechanism through which APD's exert some of their effects on brain function. (C) 1997 Elsevier Science B.V.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Clozapine; Glutamate; Haloperidol; Schizophrenia
Elenco autori:
M.A. Riva, F. Tascedda, E. Lovati, G.A. Racagni
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