Synthesis of (E)-4-(1-pyrenyl)-4-hydroxynon-2-enal, a fluorescent probe of the (E)-4-hydroxynon-2-enal with retained biological properties
Articolo
Data di Pubblicazione:
1999
Citazione:
Synthesis of (E)-4-(1-pyrenyl)-4-hydroxynon-2-enal, a fluorescent probe of the (E)-4-hydroxynon-2-enal with retained biological properties / P. Allevi, M. Anastasia, F. Cajone. - In: CHEMISTRY AND PHYSICS OF LIPIDS. - ISSN 0009-3084. - 100:1-2(1999), pp. 89-99.
Abstract:
(E)-9-(1-pyrenyl)-4-hydroxynon-2-enal (FHNE), a fluorescent probe of (E)-4-hydroxynon-2-enal (HNE) is synthesised in seven steps and in 35% overall yield, starting from commercially available 1-pyrencarboxyaldehyde. When incubated with cultured HeLa cells this fluorescent probe penetrates cells and particularly concentrates in the region surrounding the nucleus. As the parent compound, HNE it is able to induce the activation of heat shock factor (HSF) and it is able to induce the binding of HSF to heat shock element (HSE).
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
(E)-4-hydroxynon-2-enal; (E)-9-(1-pyrenyl)-4-hydroxynon-2-enal; Heat shock proteins; Lipid peroxidation
Elenco autori:
P. Allevi, M. Anastasia, F. Cajone
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