STRUCTURAL REQUIREMENTS OF ALDEHYDES PRODUCED IN LPO FOR THE ACTIVATION OF THE HEAT-SHOCK GENES IN HELA-CELLS
Articolo
Data di Pubblicazione:
1995
Citazione:
STRUCTURAL REQUIREMENTS OF ALDEHYDES PRODUCED IN LPO FOR THE ACTIVATION OF THE HEAT-SHOCK GENES IN HELA-CELLS / P. ALLEVI, M. ANASTASIA, F. CAJONE, P. CIUFFREDA, A. SANVITO. - In: FREE RADICAL BIOLOGY & MEDICINE. - ISSN 0891-5849. - 18:1(1995), pp. 107-116.
Abstract:
The ability of various aldehydes, some of which are produced in lipid peroxidation, to effect heat-shock gene expression and heat-shock proteins synthesis was evaluated in HeLa cells. Only (E)-4-hydroxyalk-2-enals were active both in racemic and homochiral form. Between the reported primary metabolic products of (E)-4-hydroxynon-2-enal, only the glutathione conjugates were active, whereas (E)-4-hydroxynon-2-enoic acid and 2-nonen-1,4-diol were inactive. Also, unnatural (E)-5-hydroxynon-2-enal and (E)-5-hydroxyhex-2-enal were active, whereas (E)-6-hydroxynon-2-enal was inactive. Thus, it was established that the active aldehydic compounds must possess an (E)-2 double bond and an hydroxy group in a position suitable for the formation of a cyclic hemiacetal in a possible adduct of these aldehydes with proteins. An irreversible binding to proteins could be the first step of the mechanism by which these compounds exert their biological activity.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
LIPID PEROXIDATION ; (E)-4-HYDROXYALK-2-ENALS ; (E)-4-HYDROXYNON-2-ENAL ; HYDROXYALDEHYDES ; (E)-4-HYDROXYNON-2-ENOIC ACID ; (E)-5-HYDROXYNON-2-ENAL ; HEAT-SHOCK PROTEINS ; FREE RADICALS
Elenco autori:
P. ALLEVI, M. ANASTASIA, F. CAJONE, P. CIUFFREDA, A. SANVITO
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