A NEW SIMPLE SYNTHESIS OF 1,3-DIDEUTERATED MALONDIALDEHYDE (3-HYDROXY[1,3-(H-2)-2]-2-PROPENAL)
Articolo
Data di Pubblicazione:
1994
Citazione:
A NEW SIMPLE SYNTHESIS OF 1,3-DIDEUTERATED MALONDIALDEHYDE (3-HYDROXY[1,3-(H-2)-2]-2-PROPENAL) / P. ALLEVI, M. ANASTASIA, P. CIUFFREDA. - In: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS. - ISSN 0362-4803. - 34:6(1994), pp. 557-563.
Abstract:
A synthetic route for obtaining 1-butoxy-1,3,3-triethoxy[1,3-H-2(2)]propane a stable diacetal of the malondialdehyde, is described. The synthesis involves the condensation of deuterated butyl vinyl ether with deuterated triethyl orthoformate in the presence of montmorillonite clay K-10. The deuteration of butyl vinyl ether was accomplished via the intermediary formation of a stannane derivative which was quantitatively metallated by n-butyllithium and then treated with (H2O)-H-2. From the diacetal the 1,3-dideuterated malondialdehyde was obtained by a short treatment with acid ion exchange resin.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
MALONDIALDEHYDE ; DIDEUTERATED MALONDIALDEHYDE ; 3-HYDROXY[1,3(H-2)-2]-2-PROPENAL ; 1-BUTOXY-1,3,3-TRIETHOXYPROPANE ; LIPID-PEROXIDATION ; ALDEHYDES
Elenco autori:
P. ALLEVI, M. ANASTASIA, P. CIUFFREDA
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