Preparation and characterization of metronidazole benzoate-gammacyclodextrin inclusion compound
Articolo
Data di Pubblicazione:
1992
Citazione:
Preparation and characterization of metronidazole benzoate-gammacyclodextrin inclusion compound / F. Giordano, G. Bruni, I.A. Hadi, M. Kata, A. Gazzaniga, G. Bettinetti. - In: BOLLETTINO CHIMICO FARMACEUTICO. - ISSN 0006-6648. - 131:4(1992), pp. 150-156.
Abstract:
Metronidazole benzoate, an antiprotozoal drug, forms a 1:1 (mol:mol) inclusion compound with gammacyclodextrin. Phase-solubility analysis, differential scanning calorimetry, X-ray diffraction on powder, and infrared spectra were used in order to characterize the inclusion compound both in solution and in the solid state. The stability of the drug to alkaline hydrolysis was improved in aqueous solutions of gamma-cyclodextrin.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
γ-cyclodextrin; FTIR; inclusion compound; metronidazole benzoate; thermal analysis; X-ray spectra
Elenco autori:
F. Giordano, G. Bruni, I.A. Hadi, M. Kata, A. Gazzaniga, G. Bettinetti
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