The non-psychoactive component of marijuana cannabidiol modulates chemotaxis and IL-10 and IL-12 production of murine macrophages both in vivo and in vitro
Articolo
Data di Pubblicazione:
2005
Citazione:
The non-psychoactive component of marijuana cannabidiol modulates chemotaxis and IL-10 and IL-12 production of murine macrophages both in vivo and in vitro / P.G. Sacerdote, C. Martucci, A. Vaccani, F. Bariselli, A.E. Panerai, A. Colombo, D. Parolaro, P. Massi. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - 159:1-2(2005), pp. 97-105. [10.1016/j.jneuroim.2004.10.003]
Abstract:
Cannabidiol is the main nonpsychoactive component of marijuana. We examined the ability of in vivo and in vitro cannabidiol to interfere with the production of interleukin (IL)-12 and IL-10 by murine macrophages and to modulate macrophage chemotaxis. Cannabidiol added in vitro to peritoneal macrophages significantly increased IL-12 and decreased IL-10 production. The CB1 and CB2 receptor antagonists prevented this modulation. Macrophages from animals treated with cannabidiol at the dose of 30 mg kg(-1) either orally or i.p. produced higher levels of IL-12 and lower levels of IL-10 in comparison to controls, and the CB receptor antagonists did not prevent these effects. Cannabidiol dose-dependently decreased fMLP-induced chemotaxis of macrophages, and the CB2 receptor antagonist prevented this decrease.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
P.G. Sacerdote, C. Martucci, A. Vaccani, F. Bariselli, A.E. Panerai, A. Colombo, D. Parolaro, P. Massi
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