Data di Pubblicazione:
1993
Citazione:
Down regulation of Qa gene expression on drug-modified tumor cells / E. Leroy, D. Lattuada, C. Casnici, P. Franco, O. Marelli. - In: TUMORI. - ISSN 0300-8916. - 79:6(1993 Dec 31), pp. 439-443.
Abstract:
Mouse leukemia, L1210, strongly enhances its immunogenicity following in vivo treatment with 5-(3-3'-dimethyl-1-triazeno) imidazole-4-carboxamide (DTIC). Previous experiments have shown that transformed cells elicit a cell-mediated response accountable for rejection and resistance to a subsequent injection of parental tumor into a syngeneic host. L1210 expresses classical H-2 class I molecules, and since it has been shown that DTIC treatment does not modify the expression of these molecules, this is a suitable model to study nonclassical class I antigens, such as Qa2 glycoproteins, and their potential role in tumorigenicity.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Animals ; Dacarbazine; Mice ; Mice, Inbred BALB C ; Gene Expression Regulation, Leukemic ; Leukemia L1210 ; Mice, Inbred DBA; Down-Regulation ; Tumor Cells, Cultured; Fluorescent Antibody Technique ; Female ; Male ; Genes, MHC Class I
Elenco autori:
E. Leroy, D. Lattuada, C. Casnici, P. Franco, O. Marelli
Link alla scheda completa: