Data di Pubblicazione:
1997
Citazione:
Inhibitory effect of somatostatin on human T lymphocytes proliferation / C. Casnici, D. Lattuada, C. Perego, P. Franco, O. Marelli. - In: INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY. - ISSN 0192-0561. - 19:11-12(1997), pp. 721-727. [10.1016/S0192-0561(97)00033-7]
Abstract:
Somatostatin (SOM) was originally described as a growth hormone release inhibiting factor, but SOM and its specific receptors (SOM-r) have been shown to be expressed on both normal and activated T and B lymphocytes and other immunocompetent cells. In the present study we have demonstrated that SOM strongly inhibits the proliferation of human T lymphocytes when stimulated by PHA, Con A or alloantigens. However, SOM was most effective when the T cells were stimulated by an alloantigen rather than a polyclonal activator such as PHA and ConA. Moreover, SOM strongly inhibited the expression of activation markers such as CD69 and CD25 that are expressed on T lymphocytes during alloantigen stimulation. SOM also inhibited both CD28 and CD2 mediated T cell proliferation. Whereas proliferation of T cells induced by the engagement of CD3 antigen using specific mAbs was only marginally affected. Our results would support the concept that in humans SOM plays a key role in the modulation of T cell activation by interfering with the antigen-independent pathways CD2 and CD28.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Human peripheral blood T lymphocytes; Neuroimmunology; Proliferation; Somatostatin
Elenco autori:
C. Casnici, D. Lattuada, C. Perego, P. Franco, O. Marelli
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