Data di Pubblicazione:
1994
Citazione:
SYNTHESIS OF A METABOLITE OF METOCLOPRAMIDE AND ITS DETECTION IN HUMAN
URINE / V. Maurich, M. De Amici, C. De Micheli. - In: IL FARMACO. - ISSN 0014-827X. - 49:12(1994), pp. 805-808.
Abstract:
The synthesis of 2-(4-amino-5-chloro-2-methoxybenzamido) acetic acid 2,
a metabolite of metoclopramide 1, has been accomplished through the
coupling of 4-amino-5-chloro-2-methoxybenzoic acid 4 with glycine benzyl
ester followed by a catalytic hydrogenation. Such a metabolite could not
be detected directly in the human urines but only after its
transformation into the corresponding methyl ester 6. Compound 6 was
prepared both by condensing acid 4 with glycine methyl ester and by
reacting acid 2 with diazomethane. HPLC analyses of biological samples
were therefore performed after treatment with diazomethane. In five
healthy volunteers, the percentage of 6 spanned the range 0.6-1.2\%.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
V. Maurich, M. De Amici, C. De Micheli
Link alla scheda completa: